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October 1, 1938

The Chemistry of Antigens and Antibodies

JAMA. 1938;111(14):1321-1322. doi:10.1001/jama.1938.02790400067034

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This report is a revised edition of report 194, published in 1935 under the same title. The usefulness of the earlier report indicated the need of revision in order to include the many important results of the work during the last few years on the chemistry of antigens and antibodies. The first chapter discusses such fundamental matters as the shapes and sizes of molecules, intermolecular (polar) forces, the structure of proteins and the stability of suspensions with special reference to antigen-antibody reactions. Then comes a consideration of the nature of antibodies, mainly from the point of view of their relation to proteins. The special topics considered are the separation of antibodies from other serum constituents, the stability of antibodies, the antigen-antibody complex, the relation of antibody globulin to normal globulin, and the increase of serum proteins on immunization. The third chapter deals with the specificity of antigens, including artificial and

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