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October 8, 1938

THE TREATMENT OF ACUTE INFECTIONS OF THE CENTRAL NERVOUS SYSTEM WITH SULFANILAMIDE

JAMA. 1938;111(15):1353-1356. doi:10.1001/jama.1938.02790410009003
Abstract

Acute infections of the central nervous system may be roughly divided into those due to viruses and those due to bacteria. Table 1 gives a list of the diseases that are certainly or probably due to viruses. To this list might be added the Guillain-Barré syndrome, which is believed by some authorities to be due to a virus and by others to be due to avitaminosis.

There has been no experimental work giving favorable results with sulfanilamide in the treatment of any of these diseases except choriomeningitis.1 With this disease it will be difficult to prove such results clinically, as patients presenting the symptoms of lymphocytic choriomeningitis usually recover before the diagnosis is established by laboratory work.

However, there is some hope that a compound of sulfanilamide may be elaborated that will affect the human virus diseases, since Dochez and Slanetz2 have shown that a derivative of sulfanilamide

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