The theory that deficiency of vitamin C may be a factor associated with rheumatic fever has been supported by clinical, experimental and epidemiologic data.1 Studies of 107 children with active rheumatic fever in 1936 indicated a greatly increased metabolic use of vitamin C in those who suffer from the infection which underlies rheumatic fever.2 Kaiser and Slavin3 have recently studied the incidence of hemolytic streptococci in the tonsils in relation to the amount of vitamin C in the blood and in the tonsils themselves. One hundred and twenty-three children had been selected by school physicians for tonsillectomy. Five cc. of blood was withdrawn from a vein and a quantitative determination of the content of vitamin C was made the following morning. The tonsils were sent to the laboratory immediately after removal and a quantitative determination of the vitamin C content was made. To determine the presence of
VITAMIN C IN THE TONSILS AND BLOOD OF CERTAIN CHILDREN. JAMA. 1938;111(18):1660–1661. doi:10.1001/jama.1938.02790440054014
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