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November 5, 1938

CHRONIC EFFECTS OF INGESTED LEAD AND ARSENICA REVIEW AND CORRELATION

JAMA. 1938;111(19):1722-1729. doi:10.1001/jama.1938.02790450004002
Abstract

The purpose of this communication is to review some of the observations presented in other papers containing the experimental details in order to correlate them with one another and with observations from the literature. Our primary interests are the comparative behavior of lead and arsenic when their salts are administered at different levels to the same species or to different species, and the correlation of physiologic and pathologic observations with results from chemical analyses.

It has been evident for some time that more extensive studies of the chronic toxicity of lead and arsenic are necessary. The growing insect infestation of fruits and vegetables has necessitated the increasing use of poisonous sprays, especially lead arsenate and calcium arsenate. The use of these has led to the serious question of whether the residues remaining on these commodities constitute a health hazard.

In formulating a law enforcement policy under the Food and Drugs

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