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November 5, 1938


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JAMA. 1938;111(19):1753-1764. doi:10.1001/jama.1938.72790450005011

It was early found that about twice as much vitamin C is required to prevent the first appearance of microscopic alterations in the teeth as to prevent the outward symptoms of scurvy in guinea pigs. It was also observed that in infants and children receiving enough vitamin C for protection against scurvy there may still develop a condition of latent or subacute scurvy accompanied by more or less severe injury to the teeth. It then became apparent that considerably larger quantities of vitamin C are required for good nutrition than for the prevention of scurvy.1

The first attempt at using human beings as subjects for the determination of requirements of vitamin C was made in Sweden in 1931 by Göthlin,2 who measured the capillary resistance or fragility of two forcibly fed schizophrenic subjects during a period on a liquid diet which at first was devoid of vitamin C

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