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November 19, 1938

The Biology of Arteriosclerosis

JAMA. 1938;111(21):1956. doi:10.1001/jama.1938.02790470068026

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This work, sumptuously illustrated in color and black and white, is a study of the results obtained by injecting suspensions of Higgins' engrossing ink into arteries and solutions of berlin blue into veins. The only variation from standard injection methods was the use of high pressures: from 800 to 1,000 mm. of mercury in the injection of coronary arteries up to 1,500 mm. of mercury in the injection of leg vessels. After injection, the tissues were cleared by the method of Spalteholz. The illustrations are for the most part drawings, with photomicrographs, some by the Kodachrome method, and photographs. There are many picturesque drawings of the various capillary and sinusoidal systems found. The authors were influenced by a hope that they could demonstrate intimal vessels in normal arteries, which previous workers had failed to do. Their work furnishes added evidence, if any were needed, that the intima of normal arteries

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