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Dérot reports studies on the creatinine concentration of serum on patients and experimental animals. He used Folin's method and found creatinine elevated in acute and chronic nephritis and other disease associated with renal lesions. In dogs and rabbits, elevated serum creatinine was brought about by nephritis produced by bismuth, mercuric chloride, and diphtheria toxin, as well as bilateral ligation of the ureters or bilateral nephrectomy. He feels that creatinine determinations are of definite help in nephritis but should be used in conjunction with urea determinations. The book contains little new. The author mentions, but does not answer, the objections to the Jaffé reaction and assumes that the error is of no clinical importance.
La créatininémie. JAMA. 1932;99(9):782. doi:10.1001/jama.1932.02740610080036
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