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November 26, 1938


Author Affiliations

Portland, Ore.

JAMA. 1938;111(22):2003-2005. doi:10.1001/jama.1938.72790480001009

Sarcoid cannot be considered a rare disease. It is, however, of considerable interest in that marked variations in clinical manifestations may occur, and it offers considerable difficulty in diagnosis in differentiating tuberculosis, syphilis and other types of proliferative granulomas.

There are several outstanding facts in the manifestations of sarcoid. The sites of particular involvement are the skin and the lymph nodes, more particularly the superficial lymph nodes; but the mediastinal lymph nodes may show massive involvement. The bones involved are most frequently those of the extremities, especially the smaller bones, where frequently destructive lesions are present. The long bones also may be involved. In a review of the literature almost every part of the body has been mentioned as being involved in this process, and while we have found reference made to involvement of the nasal bones1 we have not encountered a report of involvement of the nasal mucosa.