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November 26, 1938


JAMA. 1938;111(22):2020. doi:10.1001/jama.1938.02790480050016

The exact nature of the cellular changes in the bone marrow in aplastic anemia has received little attention despite the fact that numerous clinical studies have been made on patients with this disease. Some evidence,1 however, suggests that the abnormality is not necessarily a lack of immature forms of erythrocytes in the bone marrow, as hyperplasia of the marrow rather than aplasia is frequently found. It might be concluded, therefore, that in this type of anemia there is a failure of the normal process of maturation of the red cell. However, the fact should be emphasized that the abnormality in maturation of erythrocytes which occurs in aplastic anemia must differ from that in pernicious anemia, as liver therapy does not favorably affect the former.

The suggestion that there is an impairment in the maturation of erythrocytes in aplastic anemia has recently been investigated further2 on patients with this

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