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December 17, 1938

STUDIES ON THE MECHANISM OF THE ACTION OF SULFANILAMIDE: I. THE BEARING OF THE CHARACTER OF THE LESION ON THE EFFECTIVENESS OF THE DRUG

Author Affiliations

NEW YORK

From the Departments of Surgery and Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital.

JAMA. 1938;111(25):2259-2264. doi:10.1001/jama.1938.02790510007002
Abstract

The original observations of Domagk1 on experimental mouse peritonitis and the clinical observations reported by Schreus3 using prontosil (the disodium salt of 4-sulfamido-phenyl-2'-azo-7'-acetylamino-l'-hydroxynaphthalene-3',6' disulfonic acid) in the treatment of erysipelas led to the present investigations in April 1935. We have been interested, first, in evaluating the effectiveness and the limitations of this chemotherapeutic agent and its derivatives; second, in determiningits mode of action, and, third, in throwing light on the biology of the hemolytic streptococcus. During the course of this study an increasing number of clinical reports have appeared; the effectiveness of sulfanilamide in certain infections needs no confirmation. The present report concerns itself primarily with an attempt to determine the mode of action on a number of bacterial infections encountered in a general hospital.

The published reports on the mode of action of sulfanilamide have in most instances dealt with observations in vitro or with a single

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