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September 10, 1932


Author Affiliations


JAMA. 1932;99(11):902-905. doi:10.1001/jama.1932.02740630028007

Twenty-two years have elapsed since Herrick1 first described a case of sickle cell anemia. During this period, sixty odd cases of the condition have been reported in detail, and mention has been made in the literature of more than a hundred others. Considerable experimental work has been done in investigation of the cause and nature of sickle cell anemia, with results that sometimes conflict.

ETIOLOGY AND INCIDENCE  Sickle cell anemia is a disease of young people. The average age in the reported cases is 13 years. Only five cases have been reported in patients over 30, though one case has been reported at 62.2 The youngest patient whose case was reported was 7 months old.3 The low age incidence is explained by the fact that these patients have a decreased resistance to disease, and usually succumb early to respiratory or other infections.Males are affected more than