Adenomas of the thyroid have for long been considered, largely from their morphologic similarity to adenomas elsewhere, as true benign neoplasms. Their origin has generally been attributed to the persistence of embryonal rests, even when present in the adult gland. This idea has persisted in spite of the absence of any actual convincing proof and has contributed to the confusion and difficulties so often encountered in any attempt to correlate the pathologic and the clinical pictures.
Experimental production of nodular goiter similar to these so-called adenomas has been reported recently by Cole and Womack1 of the department of surgery at the Washington University School of Medicine. These workers studied the results of various factors, mostly chemical and infectious, which they had previously shown produce definite changes in the thyroid of dogs. They emphasize, first of all, that increases in the functional activity of the gland are produced by these
THE PATHOGENESIS OF ADENOMATOUS (NODULAR) GOITER. JAMA. 1932;99(11):919–920. doi:10.1001/jama.1932.02740630045015
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