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It is unusual for a scientific textbook to go into its thirty-fifth edition, which this handbook of physiology has done. It is still a popular book. The intervals between the last few editions have become shorter, although the number of books printed each time has been the same. New points have been added about the humoral transmission of the nerve impulse, vitamins, enzymes and sex hormones. The several sections on lymph formation, the pituitary, metabolism and diet have been completely remodeled. Some things which in former editions seemed important have been given less attention. The editors have kept in mind the needs of medical students preparing for examinations, and that accounts for some limitation of material and probably also for the popularity of the book. William S. Kirkes of St. Bartholomew's Hospital, a student of James Paget, edited the first edition in 1848. Kirkes thanks Sir James Paget for allowing
Handbook of Physiology and Biochemistry. JAMA. 1938;111(26):2419. doi:10.1001/jama.1938.02790520075037
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