The solution of the problem of adequate control of carcinoma of the uterine cervix by irradiation with roentgen rays in the region of 800,000 volts comprises the study of the clinical aspects of the disease and the etiology, the pathology and the symptomatology, incluing the extent of the disease and the action of the radiation on the tumor and the cancer cells. The investigations reported in this communication are confined to the last two factors. It may be assumed that the degree of macroscopic and microscopic changes is dependent on the dose of radiation. These changes take place during treatment and continue for some time afterward until arrest of the cancer has or has not been attained.
The observations to be reported include, therefore:
A consideration of the factors used in the production of the radiation which determine the intensity or quality of radiation and the duration in time
SCHMITZ H, SCHMITZ HE, SHEEHAN JF. THE ACTION OF MEASURED DOSES OF EIGHT HUNDRED KILOVOLT ROENTGEN RAYS: ON CARCINOMA OF THE UTERINE CERVIX. JAMA. 1939;112(1):17–22. doi:10.1001/jama.1939.02800010019004
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