[Skip to Content]
[Skip to Content Landing]
Other Articles
January 14, 1939

MODE OF ACTION, CLINICAL USE AND TOXIC MANIFESTATIONS OF SULFANILAMIDE: FURTHER OBSERVATIONS

Author Affiliations

BALTIMORE

From the biologic division of the Johns Hopkins University School of Medicine.

JAMA. 1939;112(2):115-121. doi:10.1001/jama.1939.02800020021005
Abstract

In this communication we will report further observations on the mode of action of sulfanilamide in the treatment of experimental infections and will discuss methods of therapy with sulfanilamide and the toxic manifestations which sometimes arise during the course of sulfanilamide therapy.

THE MODE OF ACTION OF SULFANILAMIDE  A year ago we1 reported that "experimental evidence shows that bacteriostasis is the only demonstrable factor in the process which leads to the control of Clostridium welchii infection in mice treated with sulfanilamide" and that "observations made by us in experimental streptococcic infections in mice treated with sulfanilamide also could be interpreted as evidence that bacteriostasis plays a role in the control of this type of infection."In our preliminary report2 we noted that sulfanilamide in a concentration of 1: 10,000 exerted a definite bacteriostatic effect in broth cultures inoculated with small numbers of beta hemolytic and alpha and gamma

×