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January 14, 1939

A Report on the Provision and Distribution of Infective Material for the Practice of Malaria-Therapy in England and Wales

JAMA. 1939;112(2):175. doi:10.1001/jama.1939.02800020081029

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The author states that there may be serious objections to the method of inducing malarial attacks by direct blood inoculation from patient to patient, especially if the donor is suffering from dementia paralytica. Under these conditions the risk of transmitting a syphilitic virus, possibly one with neurotropic characters, to a noninfected patient should never be taken. For this reason, as well as for the reason that malarial strains transmitted from patient to patient sometime become less virulent and are frequently lost, the British Ministry of Health has established an official malaria laboratory at Horton. The monograph describes the way in which mosquitoes are raised, the method of inoculating them from infected patients, the conservation of infected mosquitoes, and the feeding of the infected animals until they are shipped to the various parts of England.

The table dealing with the results of the treatment of dementia paralytica by induced malaria is

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