Nearly a century has elapsed since the first experimental investigation of the physiology of the thymus was reported by Restelli,1 and numerous investigators have since added many data, yet the function of the thymus is still to be defined accurately. We outlined in a previous publication2 the factors which we believe are responsible for the diverse opinions regarding the activity of this gland.
About two years ago we undertook to study in rats the effect of deprivation of the thymus on gastric function following roentgen therapy. We quickly recognized that striking changes occurred in the testes of the treated animals. These observations led us to a more detailed study of these effects, which constitute the chief feature of our present report.
In previous publications3 we explained why we selected the rat for study and described the method and dose of roentgen therapy used; we will give here
SHAY H, GERSHON-COHEN J, FELS SS, MERANZE DR, MERANZE T. THE THYMUS: STUDIES OF SOME CHANGES IN THE GONDAS AND PITUITARY FOLLOWING ITS DESTRUCTION BY ROENTGEN IRRADIATION. JAMA. 1939;112(4):290–292. doi:https://doi.org/10.1001/jama.1939.02800040008003
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