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To the Editor:—
In spite of the hopeful outlook in the field of bacterial chemotherapy, certain tendencies which have become obvious in the past three years should cause grave concern to serious and thoughtful students of this subject. It may be opportune to call attention to several of these in the hope that all concerned may attempt to combat these pernicious tendencies which threaten to delay advance in a field of so much importance to the health of mankind. The meaningless therapeutic experiments on mice which are constantly being published by investigators of presumably good scientific standing, the administration to human beings of chemical compounds before any detailed information of the chemical structure and properties of such compounds has been made available to medical investigators or practicing physicians, and the use of drugs in sick human beings before adequate toxicologic and pharmacologic investigation on animals is available can only impede
Marshall EK. AN UNFORTUNATE SITUATION IN THE FIELD OF BACTERIAL CHEMOTHERAPY. JAMA. 1939;112(4):352–353. doi:10.1001/jama.1939.02800040070025
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