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January 28, 1939

Zur Erblichkeitsfrage des endemischen Kretinismus: Untersuchungen an 204 Kretinen und deren Blutsverwandten

JAMA. 1939;112(4):359. doi:10.1001/jama.1939.02800040077033

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Investigating the incidence of cretinism in regions previously studied for goiter incidence (Arch. f. Hyg.81, 1913, and 111, 1933) the author found a marked similarity in geographic distribution. In localities in the cantons of Aargau and Zurich with a high goiter incidence, there were seventeen cretins among 1,677 inhabitants. In the middle range of goiter incidence there were only two cretins among 688 inhabitants, and in the endemic free localities not a single case of cretinism was found among 580 investigated in 1912 and again in 1932. The incidence of cretinic manifestations, in their various degrees of severity, was higher than previously assumed. In certain localities thirty-five cretins per thousand inhabitants were found and the average incidence was 6 per thousand for the total region previously investigated for goiter. Particularly interesting were the families studied in which cretinic characteristics marked an entire group of sisters and brothers. A greater

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