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January 28, 1939

La anemia de la enfermedad de Carrion (verruga peruana)

JAMA. 1939;112(4):360. doi:10.1001/jama.1939.02800040078037

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This is a report of investigations on the morphology of the blood and other characteristics of the anemia resulting from Carrion's disease (verruga peruana). Forty-six cases of this disease were studied and the results compared with similar observations on a hundred normal subjects. The authors conclude that the anemia which is frequent and severe in this disease is characterized by (1) its great rapidity of development, (2) macrocytosis, (3) anisocytosis and (4) hypochromemia. The degree of the last three of these characteristics was directly proportional to the severity of the anemia. The erythrocytes increased in thickness more than in diameter, tending to become spherical. Determinations made on total blood volume revealed an intense reduction in total circulating erythrocytes and hemoglobin with a compensatory increase in quantity of plasma, an increase which exceeded the erythrocyte loss in certain periods of the anemia, thereby effecting a cellular dilution. This would introduce a

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