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February 4, 1939


Author Affiliations


From the Departments of Medicine and Surgery, Rush Medical College of the University of Chicago, and the Presbyterian Hospital.

JAMA. 1939;112(5):397-403. doi:10.1001/jama.1939.02800050011003

In a recent communication to The Journal we1 demonstrated that the anterior pituitary-like principle from the urine of pregnant women may produce such marked stimulation of genital growth in young boys that a syndrome resembling premature puberty results. The present paper is concerned with the influence of this material on undescended testes.

Since Schapiro's2 report eight years ago, the anterior pituitary-like principle has been used extensively in the treatment of this condition. In spite of numerous observations in other clinics showing a high incidence of successful results, we have consistently been unable to produce descent in most instances of true cryptorchidism.3 In order to explain this discrepancy a critical survey of the problem is desirable. An analysis of the results of other observers4 is given in table 1. It may be seen that there were 860 undescended testes in 579 patients. The condition was bilateral in