Because it was observed that repeated injections of testosterone propionate inhibited the growth of the graafian follicle and definitely inhibited ovulation in the albino rat, and because when this hormone was given to the male it failed to lead to hirsutism,1 it was deemed safe to study its effect in a case of functional uterine bleeding.
A white married woman aged 35 had been obese for five years and had had excessive vaginal bleeding for about ten years. Her family history was irrelevant. She had been stout as a child but had otherwise been healthy. Menstruation began at the age of 13 and had recurred every twenty-eight days for a duration of three days, with neither pain nor discomfort, until ten years before. At that time the duration began to increase, and after a few months each period lasted nine days, although the twenty-eight day cycle was maintained. For
Rubinstein HS. TESTOSTERONE PROPIONATE IN THE TREATMENT OF FUNCTIONAL UTERINE BLEEDING. JAMA. 1939;112(6):537–538. doi:10.1001/jama.1939.62800060001011
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