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To the Editor:
—The opportunity for any one physician to treat any considerable number of patients with infectious mononucleosis is obviously limited. Even as an attending physician on the staff of a large municipal hospital I observe only a few cases a year. One of my patients, a girl of 17, with infectious mononucleosis, ran a temperature of over 104 F for more than a week that failed to respond to the usual antipyretics. Immune globulin, 4 cc., was given. There was a prompt fall in temperature within 24 hours. I have not had the opportunity to repeat this observation. I offer the preceding observation in the hope that it may be of value to others in a similar situation. The purpose of using immune globulin was not primarily to favorably affect the illness directly, although such an event was hoped for, but to prevent if possible the development of
Freund H. GAMMA GLOBULIN AND INFECTIOUS MONONUCLEOSIS. JAMA. 1953;152(1):77. doi:10.1001/jama.1953.03690010083032
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