The extensive use of oils in pediatric practice, both as food and for therapeutic purposes, has been attended in some instances with unexpected pulmonary complications; unexpected, because it was not realized until pointed out by a number of observers, that oils, when given to young children either orally or through the nasopharynx, not infrequently pass into the trachea and ultimately reach the alveoli of the lungs. Having reached the alveoli, the fats and oils initiate an interesting pathologic process. The earliest literature pertaining to these pathologic changes refers to experiments done on animals. In 1920, Guieysse-Pellissier1 described the changes in the lungs of rabbits and dogs following the intratracheal injection of olive oil. He found that the alveoli of the lungs were filled with many large mononuclear cells containing oil, polymorphonuclears and eosinophils. Corper and Fried,2 in 1922, described similar changes resulting from the use of olive oil,
PIERSON JW. PNEUMONIA DUE TO THE ASPIRATION OF LIPOIDS. JAMA. 1932;99(14):1163–1165. doi:10.1001/jama.1932.02740660041009
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