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February 11, 1939

Sulfanilamide Therapy of Bacterial Infections with Special Reference to Diseases Caused by Hemolytic Streptococci, Pneumococci, Meningococci and Gonococci

JAMA. 1939;112(6):574. doi:10.1001/jama.1939.02800060090028

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This volume is an excellent reference work on sulfanilamide and its early clinical use. Under chemistry the authors list practically every therapeutic compound which is related to sulfanilamide and neoprontosil. The chapter on pharmacology contains frequent reference to the literature in support of the statements, increasing the value of the material presented. Experimental work, chemotherapeutic results, bacteriostatic effects and therapeutic use of the preparation are discussed. Other chapters deal with the various factors which enter into its use in therapeutics, including the cellular defenses, the fitness of the host, and natural resistance. Comparative bacteriostatic effects and the criteria of therapeutic efficiency are described. There is a bibliography of 305 references and an addendum covering the period between the time the manuscript went to press and the date of publication. This addendum includes references to photosensitization, sulfhemoglobinemia, the use of sulfanilamide in staphylococcic infections, and its relationship to the filtrable viruses,

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