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Lipodystrophy is a disorder in which there is a loss of subcutaneous fat. The loss is absolute in that in the affected areas there is a complete absence of the subcutaneous tissue fat. None of the other tissues seem to be involved. The face is affected most commonly and more markedly than other parts of the body. The absence of fat is not congenital, because in affected persons the fat has previously been present in the regions from which it disappears. In some reported cases there has been an apparent increase in the fat of the lower part of the body. The condition is undoubtedly a disease entity rather than a symptom complex because of the absence of any other clinical, physical or pathologic manifestations. In association with other diseases there may be a marked decrease in the amount of subcutaneous fat but the fat loss is never absolute. The
Bigler JA. LOSS OF SUBCUTANEOUS FAT OF THE LOWER EXTREMITIES (LIPODYSTROPHY). JAMA. 1939;112(7):627–628. doi:10.1001/jama.1939.62800070001010
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