Dees and Colston1 introduced sulfanilamide in the treatment of gonorrhea in February 1937. Their preliminary report indicated that it might end the search for a practical check of this widespread venereal disease. Since then, diverse results have been reported. Reuter's2 most closely approximated the original report, but Potter,3 in a series of 225 cases, reported only 35 per cent cures. Brunet's4 percentage of cures was also low. Johnson and Pepper's5 results were so disappointing as to evoke an editorial6 in The Journal pointing to less than 50 per cent cures and calling for extreme caution in the use of the drug.
Although the drug itself was completely exonerated by the Council on Pharmacy and Chemistry of the American Medical Association for the deaths following the use of Massengill's elixir of sulfanilamide, it is as yet not completely free from this onus in the public
SILVER B, ELLIOTT M. THE USE OF SULFANILAMIDE IN 1,625 CASES OF GONORRHEA IN THE MALE. JAMA. 1939;112(8):723–729. doi:10.1001/jama.1939.02800080043010
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