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November 5, 1949

PERIODIC DISEASE

JAMA. 1949;141(10):738. doi:10.1001/jama.1949.02910100104022

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Abstract

To the Editor:—  Reimann's paper on "Periodic Disease" in The Journal, Sept. 17, 1949, suggests relationships among conditions previously described as distinct entities. In support of this concept, I should like to cite my own experience in 16 cases of benign paroxysmal peritonitis. Three patients had intermittent arthralgia, at times with joint swelling, as an alternative form of attack appearing between their major abdominal crises. Two patients had urticaria, although only in the earlier years of their illness. One patient had on rare occasions an episode of fever without abdominal pain. In none of the 16 cases was there purpura, angioneurotic edema, periodic paralysis or neutropenia.I am not in accord with Reimann's designation of benign paroxysmal peritonitis as "periodic abdominalgia." This term, which signifies merely recurrent abdominal pain, does not in any sense describe the remarkable clinical picture of the paroxysms of the disease. They are characterized not only

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