[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Other Articles
May 11, 1946

RADIOACTIVE IODINE IN THE STUDY OF THYROID PHYSIOLOGY: VII. The Use of Radioactive Iodine Therapy in Hyperthyroidism

Author Affiliations

Boston; Cambridge, Mass.

From the Thyroid Clinic and Metabolism Laboratory of the Massachusetts General Hospital and the Radioactivity Center, Massachusetts Institute of Technology. This material was presented in part to the American Society for Clinical Investigation in May 1942 (see abstract of proceedings, Physiol. Rev. 62:4, 1942). The work was aided by a grant from the John and Mary R. Markle Fund in the names of Professors J. H. Means and Robley D. Evans and was accomplished by close cooperation of the Radioactivity Center of the Massachusetts Institute of Technology, Cambridge, Mass., and the members of the medical staff of the Massachusetts General Hospital, Boston.

JAMA. 1946;131(2):81-86. doi:10.1001/jama.1946.02870190005002

In previously published experiments of this series1 radioactive iodine was used as an indicator in the study of animal and human thyroid physiology and iodine metabolism. Much of this preliminary work was done with a view to the discovery of the conditions under which radioactive iodine might be administered with maximum radiational effect in the pathologic thyroid of patients ill with hyperthyroidism. The present paper is a progress report on our early experiences (1941-1946) with such "internal irradiation" in the treatment of 29 cases of hyperthyroidism. It is, indeed, a three to five year follow-up report on these cases.

PROCEDURE  Patients were selected who had had no previous iodine treatment and who were judged clinically to have hyperthyroidism. The usual clinical tests were made and the patients were presented to the Thyroid Clinic of the Massachusetts General Hospital for discussion and determination of their suitability for this type of