The successful use of oral or parenteral nicotinic acid in the treatment of certain special types of cephalalgia, such as migraine, malarial headache or sinus headache, has been reported within recent years. Although these studies were very promising, they were of necessity limited in scope. For this reason it was decided to investigate the effect of sodium nicotinate on a sufficiently large series of headaches regardless of etiology, and to determine if possible what types are suitable for vasodilator therapy.
MATERIALS AND METHODS
In our experiments sodium nicotinate was used except in a few instances in which niacin was substituted.1 The intravenous route of administration was chosen for precision and the decisiveness of the clinical effect; 100 mg. of nicotinic acid or its equivalent as the sodium salt was taken as the standard dose because this amount was found adequate to produce a flush in almost every case. One
GOLDZIEHER JW, POPKIN GL. TREATMENT OF HEADACHE WITH INTRAVENOUS SODIUM NICOTINATE. JAMA. 1946;131(2):103–105. doi:10.1001/jama.1946.02870190027007
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