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March 11, 1939

CHANGES IN CELLS AFTER FRACTIONAL DOSES OF X-RAYS

JAMA. 1939;112(10):1010. doi:10.1001/jama.1939.02800100120022

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Abstract

To the Editor:—  In a recent article in The Journal (Schmitz, Henry; Schmitz, H. E., and Sheehan, J. F.: The Action of Measured Doses of Eight Hundred Kilovolt Roentgen Rays, January 7, p. 17) the authors describe, among other changes, the finding of large numbers of degenerating giant tumor cells in squamous cell carcinoma of the uterine cervix treated by fractional doses of x-rays. We reported this finding in tumors in experimental animals at the International Congress of Radiology in 1937 and in the Archives of Pathology (23:757 [June] 1937), and we are pleased that the same picture has now been observed in human cancer. One of us (P. J. M.) has also observed the phenomenon in several varieties of irradiated human cancer.Although occasional giant tumor cells have been seen by a number of workers, they develop in abundance only in the later stages of treatment by fractional

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