For the past five years I have employed an extract, representing the active substance or hormone (interrenalin) of the adrenal1 cortex, in the treatment of Addison's disease. Sixty-two cases have come under my observation for study and treatment. This has enabled me to correlate clinical observations with my studies on adrenal insufficiency in experimental animals.
In 1929, Stewart and I2 published a preliminary report on the treatment of Addison's disease by oral administration of extracts prepared from the cortical layer (interrenal gland substance) of adrenal glands. At that time we reported our observations on seven patients who had been receiving "interrenalin" for periods up to about one and one-half years. In 1930, I3 compared the periods of survival and clinical courses of these patients with those of patients that had not received adrenal extract. The contrast was sufficiently great to demonstrate superiority of this treatment over others
ROGOFF M. ADDISON'S DISEASE: FURTHER REPORT ON TREATMENT WITH "INTERRENALIN" (ADRENAL CORTICAL EXTRACT). JAMA. 1932;99(16):1309–1315. doi:10.1001/jama.1932.02740680005002
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