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March 25, 1939

THE POTENCY OF DIGITALIS STANDARDIZED ACCORDING TO U. S. P. XI

Author Affiliations

Newark, N. J.

JAMA. 1939;112(12):1181. doi:10.1001/jama.1939.02800120066024

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Abstract

To the Editor:—  The confusion concerning digitalis standardization is illustrated by a comparison of the opinions of two eminent authorities printed within a period of three weeks in The Journal.On Dec. 17, 1938, in "The Treatment of Cardiac Irregularities," George Fahr (page 2269, footnote 5) states: "At present digitalis is standardized according to the U. S. P. XI so that 0.65 cc. of the tincture or 0.065 Gm. (1 grain) of the powdered leaf is 1 Hatcher-Brody cat unit. In the previous editions of the U. S. Pharmacopeia 1 cc. of tincture or 0.1 Gm. of the powdered leaf contained 1 cat unit. One-tenth gram (1 1/2 grains) of the standard U. S. P. XI powder is equivalent to 1.6 Hatcher-Brody cat unit."On January 7, in "Drug Therapy in Coronary Disease" Harry Gold (page 5) states: "A satisfactory dosage in the average case of auricular fibrillation or heart

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