The possibility of obtaining relief of asthmatic symptoms by the direct application of a solution of epinephrine to the bronchial mucosa was reported by Ephraim1 as early as 1910. Through the bronchoscope he first observed blanching of the mucous membrane after subcutaneous administration of epinephrine. Subsequently, epinephrine solution was sprayed directly into the bronchi through the bronchoscope with definite relief of asthmatic symptoms. In a later communication Ephraim2 repeated these observations and commented on the beneficial effect of procaine hydrochloride alone, although he said that greater benefit resulted from the epinephrine. Thereafter, other authors reported the efficacy of the inhalation of epinephrine solutions for the relief of asthmatic symptoms. The earler of these were Krause,3 Segel4 and Zuelzer.5 In later years a number of reports have been made concerning this procedure, such as those of Grunwald,6 Sachse,7 Weiss and Magassy,8 Camps,9
GRAESER JB. INHALATION THERAPY OF BRONCHIAL ASTHMA. JAMA. 1939;112(13):1223–1226. doi:10.1001/jama.1939.02800130007003
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