Opinion as to whether or not the presence of Endamoeba histolytica, the dysentery-producing ameba, in the human bowel is necessarily associated with invasion of tissue varies with different investigators. Thus, extreme views in favor of such an hypothesis were expressed by Dobell and O'Connor1 in 1921 when they stated that "infection with this parasite [i. e., E. histolytica] must always produce a more or less pathological condition of the colon." Acton and Knowles2 believed that "mild ulceration of the colon mucosa" takes place in the carrier condition. According to Boyers, Kofoid and Swezey,3 "a constant search has been made for a true carrier, but as yet only one individual has been found by the medical author in more than 500 cases who showed no visible tissue damage attributable to E. dysenteriae." Craig,4 in 1926, stated that "Endamoeba histolytica is a true tissue parasite living upon the
Andrews J, Atchley F. NEGATIVE OCCULT BLOOD TESTS IN CARRIERS OF THE DYSENTERY-PRODUCING ENDAMOEBA HISTOLYTICA. JAMA. 1932;99(16):1340–1342. doi:10.1001/jama.1932.27410680001010
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