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April 1, 1939


Author Affiliations


From the Departments of Orthopedic Surgery of the Los Angeles County Hospital and the University of Southern California School of Medicine.

JAMA. 1939;112(13):1233-1237. doi:10.1001/jama.1939.02800130017006

The surgical and pathologic aspects of bone and joint involvement in coccidioidal granuloma have received little attention in published articles. Twenty-four such cases have been studied and form the basis of this report. The condition is quite often misdiagnosed as either a pyogenic or a tuberculous lesion.

Wernicke1 reported the first case of coccidioidal granuloma in 1892 from South America. Rixford and Thorne2 reported two cases from California in 1894 and two years later Rixford and Gilchrist3 gave a detailed report of these two cases and suggested the name Coccidioides immitis for the organism, which was later termed Oidium coccidioides and the disease coccidioidal granuloma by Ophüls4 in 1905. The exact classification of the organism is still unsettled. The North and South American strains of the disease have been presented by Jordon and Weidman.5

Numerous reports dealing with the condition to 1931 are listed by