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July 11, 1953


Author Affiliations

Veterans Administration Center Wilshire and Sawtelle Blvds. Los Angeles 25.

JAMA. 1953;152(11):1066. doi:10.1001/jama.1953.03690110080026

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To the Editor:  —Dr. Hyman Engelberg discussed our article on heparin and angina and made several statements that require amplification (J. A. M. A.152:474 [May 30] 1953). His statement that "nearly all" of our patients had had angina for five years is inaccurate. In our article, we stated that this was true of the "majority" (over 50%). His statement that angina of this duration would be associated with "probably markedly calcific vessels" must remain a surmise, in the absence of anatomic confirmation. We are surprised that he considers angina of this duration a disqualifying feature, since he reported on 27 patients (Am. J. M. Sc.224:487, 1952), 12 of whom had had angina for four or more years. He reported improvement with heparin in 7 (58%) of these 12 patients and in 10 (66%) of the remaining 15 patients. The difference has no statistical validity and does

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