Deaths related to the injection of foreign protein in man are fortunately few. The exact number of such occurrences is difficult to estimate from the available literature. By 1942 Kojis1 was able to find 61 such deaths, and he added 4 more from the Willard Parker Hospital. The most complete and most recent study of necropsies was made by Vance and Strassmann,2 who added 7 autopsy studies from the Office of the Chief Medical Examiner to 19 taken from the literature. Park3 in 1932 recorded the mortality from serum anaphylaxis as 0.002 per cent. Kojis1 in 1942 found it to be just under 0.1 per cent in a series of 6,211 subjects treated for various infections. Rutstein and his associates,4 in their analysis of pneumonia cases treated with antipneumococcus horse serum, found the mortality to be 0.45 per cent. In only 1 or possibly 2
WERNE J, GARROW I. FATAL ANAPHYLACTIC SHOCK: Occurrence in Identical Twins Following Second Injection of Diphtheria Toxoid and Pertussis Antigen. JAMA. 1946;131(9):730–735. doi:10.1001/jama.1946.02870260014003
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.