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April 8, 1939


JAMA. 1939;112(14):1344. doi:10.1001/jama.1939.02800140042013

Recently D. R. Drury1 of the Department of Physiology, University of Southern California, has described a new method for the production of renal insufficiency of any desired grade in rabbits without the production of pathologic changes in the kidney epithelium. Numerous methods for the production of renal insufficiency in laboratory animals have been devised by previous investigators, such as the administration of nephrotoxins or other bacterial products, exposure to x-rays, surgical removal of one kidney with partial ablation of the other and, more recently, the application of Goldblatt ischemic clamps to the renal arteries. By all these technics, however, necrosis or other pathologic changes are produced in kidney tissue, particularly in rabbits. To avoid such cellular degenerations and to produce a purely quantitative reduction in renal function, Drury placed a loose silk ligature about the left renal artery of baby rabbits (400 Gm.) and allowed this loop to serve