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To the Editor:
—In a communication to The Journal, September 3, Dr. V. W. Jensen reported a reaction after the subcutaneous and submucous injection of nupercaine prior to a hemorrhoidectomy. The reaction consisted of dizziness, nausea, vomiting, loss of bladder and rectal control and unconsciousness. The reaction was not fatal.Dr. Jensen states that he used from 5 to 6 cc. of a 1 per cent nupercaine solution. Although this may seem like a very small dose, it is in reality a very large dose. The regular concentration of nupercaine that is used for subcutaneous injection is a 1:1,000 solution. The amount of nupercaine used in the case reported was between 50 and 60 mg., which would be as much as from 50 to 60 cc. of a 1: 1,000 solution.I think this reaction can be attributed to an overdosage of the drug. When used in the 1: 1,000
Arnheim EE. TOXICITY OF NUPERCAINE. JAMA. 1932;99(16):1373. doi:10.1001/jama.1932.02740680069031
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