Since the occurrence of pseudoalbuminuria after ingestion of iodoalphionic acid (Priodax)1 and Monophen (2-[4-hydroxy-3,5-diiodobenzyl]-cyclohexane carboxylic acid)2 was reported, another cholecystographic medium, Telepaque (3- [3- amino- 2,4,6- triiodophenyl]-2-ethylpropanoic acid), has been employed successfully. Telepaque is a solid containing 66.68% iodine, while iodoalphionic acid contains 51.5% and Monophen 52.2% iodine. Experiments with animals at the Sterling-Winthrop Research Institute have shown that Telepaque, taken orally, is eliminated mainly by the gastrointestinal tract but to some extent by the kidneys.
As a fairly high incidence of pseudoalbuminuria was found after ingestion of iodoalphionic acid and Monophen,2 study of Telepaque was undertaken to determine whether the small amount of this drug eliminated through the urinary tract was sufficient to cause pseudoalbuminuria. Chemical examination of the substance showed that it readily dissolved in water. When the solution was acidified, a flocculent precipitate appeared, and, when it was alkalized, the precipitate disappeared.
Seedorf EE, Powell WN, Greenlee RG, Dysart DN. TELEPAQUE AND PSEUDOALBUMINURIA. JAMA. 1953;152(14):1332–1333. doi:10.1001/jama.1953.63690140004008a
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: