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April 22, 1939

CHRONIC ULCER OF THE LEG ASSOCIATED WITH CONGENITAL HEMOLYTIC JAUNDICE

Author Affiliations

New York

From the Department of Surgery, Columbia University College of Physicians and Surgeons, and the Spleen Clinic, Presbyterian Hospital.

JAMA. 1939;112(16):1574-1576. doi:10.1001/jama.1939.62800160002010a
Abstract

Since the beginning of the century a considerable literature has accumulated concerning hemolytic jaundice. In 1900 Minkowski and later Chauffard described the congenital type, and between 1907 and 1911 Hayem Widal and his associates presented a group which they considered to be "acquired." Attention was first called to the disease in this country by Tileston and Griffin1 in 1910. Subsequently the excellent studies of Gänsslen,2 Eppinger3 and Meulengracht4 completed the clinical picture of the disease as it is known today. Dawson5 and others have presented considerable evidence to show that the acquired and the congenital types are closely related and have cast considerable doubt as to whether any cases that rightfully belong to this group are actually "acquired." Haden's 6 work demonstrated that the spherical microcyte is the fundamental variation from the normal in this disease and that "the anemia, jaundice, splenomegaly, reticulocytosis and increased

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