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April 22, 1939

Current Comment

JAMA. 1939;112(16):1595. doi:10.1001/jama.1939.02800160059016

THE ABORTIFACIENT AND OTHER EFFECTS OF THE URINE AND SERUM OF CANCEROUS PATIENTS  Elsasser and Wallace1 recently reported that the urine and serum of patients with malignant tumors have a selective action on embryonal or newly growing tissue. The work began with the urine of a man with an embryonic cancer of the right testicle. Daily intravenous injections in pregnant rabbits of 20 cc. of urine produced abortion on the fifth day. The urine of patients with other tumors of embryonal nature—dysgerminoma of the ovary, teratoma of the testicle, Wilms tumor—produced abortion, as did "the urine of a large number of patients with other types of malignant tumors" (no further details are given). The blood serum of patients whose urine caused abortion also was effective. Control tests with the urine or serum of normal persons and of noncancerous ward patients gave negative results. Following the daily injections of urine