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April 22, 1939

Beitrag zur Kenntnis sklerosierender Entmarkungsprozesse im Gehirn, mit besonderer Berücksichtigung der diffusen Sklerose (Strümpell-Heubner): Eine klinisch-anatomische Studie

JAMA. 1939;112(16):1632. doi:10.1001/jama.1939.02800160096040

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Abstract

This monograph is based on a careful clinical and microscopic study of six new cases of demyelinizing lesions of the brain. In four of these cases the condition belonged to the class of the Strümpell-Heubner diffuse scleroses and in the other two it was difficult to classify. On the basis of this study the authors come to a new classification of the demyelinizing diseases and attempt to interpret cases reported in the literature in the light of their new conception. They distinguish five types: (1) the blastomatous reactive form, (2) the exogenous inflammatory form, (3) the nonfamilial degenerative form, (4) the heredodegenerative familial form and (5) the peculiar concentric sclerosis of Baló. They propose as a generic term for all these lesions "leukoencephalopathia scleroticans diffusa." Their classification is based on the microscopic appearances, and they believe that with all these lesions many and varied etiologic factors play a part simultaneously.

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