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August 10, 1946


JAMA. 1946;131(15):1213-1214. doi:10.1001/jama.1946.02870320031013

In 1929 McKinney1 observed that plants infected with tobacco mosaic virus resist infection with a variant strain of homologous virus. Numerous other examples of both homologous and heterologous interference between, plant viruses were subsequently reported. Six years later similar interference phenomena were reported between animal viruses. Hoskins,2 for example, found that in monkeys a neurotropic strain of yellow fever virus blocks a concurrent infection with a viscerotropic strain of the same virus. Dalldorf3 observed a reciprocal "sparing effect" between poliomyelitis virus and that of lymphocytic choriomeningitis. Jungeblut and Sanders4 demonstrated a similar interference between simian and murine poliomyelitis viruses. Such interference between animal viruses has been demonstrated not only in intact animals but in tissue cultures5 and in embryonated eggs.6

The possibility of practical application of virus interference therapy was suggested by Ziegler,7 who found that an influenza A or B virus rendered