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January 14, 1950


Author Affiliations

Philadelphia 46.

JAMA. 1950;142(2):125-126. doi:10.1001/jama.1950.02910200053023

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To the Editor:—  Virus causation of recurrent aphthous ulcers has not been proved. As recently as Oct. 1, 1949 (J. A. M. A. 141: 362, 1949) and Sept. 24, 1949 (J. A. M. A. 141:299, 1949) in "Queries and Minor Notes" the consultants repeated the erroneous concept that this disease is caused by the virus of herpes simplex. In addition, one of the writers misquoted studies from this laboratory by indicating that there is significant alteration in antibody titer in patients with recurrent herpes simplex. We are taking this opportunity to correct these errors and to present a brief summary of our combined clinical and laboratory observations which are pertinent to the problem of recurrent ulcers of the mouth.As part of a larger joint study of virus diseases of the skin by the departments of dermatology and pediatrics of the University of Pennsylvania at the Children's Hospital of

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