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January 21, 1950


Author Affiliations


Member of the American Academy of General Practice.; Chief of Medical Service 2, Community Hospital, Philadelphia.

JAMA. 1950;142(3):173-175. doi:10.1001/jama.1950.72910210001008

One of the problems of the practitioner is how best to maintain effective blood levels of penicillin or streptomycin when treating the more resistant infection in the home and office. Although the majority of infectious disorders respond to repository penicillin preparations administered once daily, Tompsett and co-workers1 suggest that suppurative complications in penumonia are less likely to occur when penicillin is administered at frequent intervals. Waldbott,2 reporting on the control of infections in asthma, states that he prefers the frequent administration of crystalline penicillin to the use of aerosol or injections of procaine penicillin. Herrel3 warns against treating severe infections such as bacteremia with injections of penicillin either once or twice daily.

While streptomycin is a most potent antibiotic agent, the occasional occurrence of toxic disturbances discourages its wider use. To prevent these harmful reactions, Kolmer4 advises the combined use of penicillin and streptomycin, since smaller