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August 31, 1946


Author Affiliations

Medical Director, Chief, Venereal Disease Division, United States Public Health Service Washington, D. C.

JAMA. 1946;131(18):1480-1482. doi:10.1001/jama.1946.02870350012003

My purpose in this report is threefold: to present data from the most recent Public Health Service investigations on the use of penicillin in gonorrhea by short treatment schedules, to review data from certain previous studies of the Public Health Service and to indicate the practicability of reducing the incidence of gonorrhea through the use of these short schedules of treatment in the private physician's office.

That penicillin is an effective therapeutic agent for gonorrhea seems well established; and there is general agreement that, with the commercial penicillins as now produced, satisfactory results may be expected with a total dosage of 200,000 Oxford units or more. The major consideration remaining at the moment concerns the best schedule for administering the penicillin. Ideally, the best schedule would require a minimum of time and a minimumof special equipment without any sacrifice of therapeutic efficacy. Ideally too, the most desirable schedule would be