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January 28, 1950


JAMA. 1950;142(4):276-277. doi:10.1001/jama.1950.02910220056023

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To the Editor:—  The case discussed in a current comment in The Journal, Dec. 3, 1949, page 996, is unusual. A hemolytic reaction following a blood transfusion is usually due to some clerical or technical error involving the A-B-O groups or the Rho factor. In addition to the A-B-O groups and the Rho factor, there are many other blood factors which at times have given rise to isosensitization, such as the M, N and S factors, the P factor, the factors, rh', rh", hr', hr" and rhw, the Lewis factor and the Kell factor mentioned in Dr. Chown's article. If the mother's blood lacks any of these blood factors and the fetus inherits the factor in question from the father who possesses it, the possibility of isosensitization is present. Therefore, to be consistent one should type every patient requiring a blood transfusion not only for A-B-O and Rho factors, but

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