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The author reviews the anatomic and pathologic aspects of thrombosis. He concurs in the view that emboli are derived from fresh thrombi and that those which occur in the third week following venous thrombosis result from newly formed thrombi. While he has established anatomic considerations well, certain physiologic conclusions lack the necessary evidence, for example that the femoral vein may be empty in a bedridden patient. The fact that in the prone position the blood travels in the femoral vein up a 34 per cent grade is important in the genesis of thrombophlebitis. The etiology of venous thrombosis is extensively reviewed but no new contributions are made. The author's main objectives in the management of thrombophlebitis are fixation of the thrombus and restoration of circulation. He believes that ambulatory patients with phlebitis should remain ambulatory and that patients confined to bed when phlebitis occurs should be put through a series
Die Therapie der Thrombose. JAMA. 1939;112(18):1860. doi:10.1001/jama.1939.02800180084045
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